How to setup Activesync email in Mac OS X Lion?

I have downloaded and installed Lion. I would like to make use of some features of new mail, in particular, want to sync with my work e-mail. I used Active Sync and it works fine with my iPhone and iPad. On the other hand, I cannot run the mail on my iMac (Intel), even with the promised new-fangled functionality in Mac OS X Lion, but it just keeps saying there is no response from port 403, why? How to setup Activesync email in Mac OS X Lion? Please help. Thanks

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